I'm not sure how many actual deaths were in official "studies", but there were many in the press and often they were young women (teens-20's, but there was a famous model in her 30's, but I can't remember her name). It was good at that too - better than pseudoephredine and it was marketed as an anorexiant in addition to a decongestant (are you old enough to remember Dexatrim, Acutrim?-these were phenylpropanolamine). None of this was bad for years because it was used, like the other decongestants, for use in colds, hay fever, etc.However, in the late 70's, early 80's.there was a big push for anoriexants.
Part of its peripheral action was due to release of norepinephrine which resulted in increased BP - in a small way due to vasoconstriction, but mostly due to cardiac stimulation. PPA was great because it caused less central stimulation than ephedrine, but it caused greater peripheral stimulation than pseudoephedrine. Both phenylpropanolamine & pseudoephedrine stimulate both alpha & beta. Now - you asked about PPA & why its not around? Most all decongestants stimulate alpha adrenergic receptors of vascular smooth muscle. Now.its different for those folks who use it on a more regular basis - flyers who have chronically obstructed eustachian tubes & really need dependable decongestion or others like them.
Whether this cold is worse than the one they had last year - who knows, so difficult to compare. My thoughts on Sudafed & Sudafed PE are they are fine & interchangeable for the short term "cold" symptoms - I reassure folks their cold will resolve in 5-7 days anyway.
0 kommentar(er)
